association of a bacteriophage with meningococcal disease in young adults协会的脑膜炎球菌病的噬菌体的年轻人.pdf

Association of a Bacteriophage with Meningococcal Disease in Young Adults 1,2,3. 4.¤ 5 5 4 Emmanuelle Bille , Roisin Ure , Stephen J. Gray , Edward B. Kaczmarski , Noel D. McCarthy , 1,2,3 4 1,2,6 Xavier Nassif , Martin C. J. Maiden , Colin R. Tinsley * ´ ´ ´ ´ ´ ´ ´ 1 Institut National de la Sante et de la Recherche Medicale, Paris, France, 2 Unite de pathogenie des infections systemiques, Universite Paris Descartes, Faculte de ´ ˆ ˆ Medecine, Paris, France, 3 Laboratoire de Microbiologie, Assistance Publique-Hopitaux de Paris, Hopital Necker-Enfants Malades, Paris, France, 4 Department of Zoology, Peter Medawar Building for Pathogen research, Oxford, United Kingdom, 5 Meningococcal Reference Unit, Health Protection Agency, Manchester Royal Infirmary, ´ ´ ´ Manchester, United Kingdom, 6 Laboratoire de Microbiologie et Genetique Moleculaire, UMR AgroParisTech/INRA 1238/CNRS 2585, AgroParisTech, Centre de Grignon, Thiverval-Grignon, France Abstract Despite being the agent of life-threatening meningitis, Neisseria meningitidis is usually carried asymptomatically in the nasopharynx of humans and only occasionally causes disease. The genetic bases for virulence have not been entirely elucidated and the search