膳食铁摄入和妊娠期糖尿病的相关性研究.doc

膳食铁摄入与妊娠期糖尿病的相关性研究 通讯作者：吴金凤，电子邮箱：841097230@ 吴金凤1 顾平1 王颖1 朱荣2 1 南京医科大学护理学院，南京，210029 2 南京医科大学附属南京市妇幼保健院产科门诊，南京，210004 摘要： 目的 探索膳食铁摄入与妊娠期糖尿病（GDM）的相关性，为GDM的防治提供参考。 方法 在产检孕妇中，根据OGTT（75g糖耐量试验）筛选出GDM患者108例为GDM组，随机选择糖耐量正常孕妇108例作为对照组进行病例对照研究。通过问卷调查、膳食调查和铁负荷水平检测，比较两组孕妇膳食铁摄入量和铁负荷指标的差异，并采用多因素Logistic回归分析计算GDM与高膳食铁摄入的OR值。 结果 GDM组孕妇膳食铁摄入量显著高于对照组（P＜0.01）；GDM组血清铁蛋白水平为（84.64+68.19）vg/L，与对照组（57.87+55.77）vg/L比较，差异有统计学意义（P=0.002）；高膳食铁摄入与GDM患病风险的OR值为1.037（置信区间为1.007-1.069）。 结论 高水平膳食铁摄入与GDM的患病风险存在正相关。 关键词：妊娠；糖尿病；膳食；铁负荷 Correlation study on dietary iron intake and gestational diabetes mellitus(GDM) Author: Wu Jinfeng1, Gu Ping,1 Wang Ying,1 Zhu Rong2 1 (Nanjing Medical University, Nanjing,210029) 2 (Nanjing Maternal and Child Health Hospital Affiliated to NJMU，Nanjing 210004) Abstract [Objective] To explore the correlation between dietary iron intake and gestational diabetes mellitus(GDM), aiming to provide a reference for the prevention of GDM. [Methods] Slecting 108 cases of GDM in prenatal women according to OGTT (75-g glucose tolerance test), randomly selected 108 cases of pregnant women with normal glucose tolerance as the control group. Case-control study was carried out between the two groups. Through questionnaire survey, dietary survey and detection of iron overload level, the dietary iron intake and iron overload index were compared between the two groups. The OR values between GDM and its risk factors were analyzed by using multi-factor regression analysis. [Results] The dietary iron intake in GDM was significantly higher than that in the control group(P＜0.01). The mean serum ferritin in GDM was (84.64+68.19)vg/L, which was higher than the value of normal group(57.87+55.77)vg/L, the difference was significant(P=0.002). The OR value of high dietary iron intake and risk of GDM was 1.037(confidence interval was 1.007-1.069). [Conclusion] The high level of dietary iron intake is positively correlated with GDM. Key Words: Gestatio