肝病专科医院10年来住院病人疾病谱变化调查_沈玲.pdf

东南大学学报 ( 医学版) 　2004 ,Mar ;23 (2) :99103 J Sout heast U niv (Med Sci Edi) ·99 · 　　　　　　 ( ) GC and it s relationship wit h clinicop at hological feat ures of GC. Methods 　M SI was examined in 30 surgically re sected GC specimens using PCR , PCRdenat ured polyacrylamide gel based met hods. Results 　M SI was detected in 36 . 67 % ( 11/ 30) of GC. No significant correlation was found between M SI st at us and age ,sex ,clinical st age ,lymp h node met ast asis and histological types of GC ( P 0 . 05) ,but t here seems a correlation between M SI and differentia tion or location of GC. The incidence of M SIH ( highlevel M SI) in well or moderately differentiated GC ( 8/ 17 , 47 . 06 %) was significantly higher t han t hat in poorly differentiated GC ( 1/ 13 ,7 . 69 %) ( P 0 . 05) ,and M SIH oc curred more frequently in GC located in ant rum ( 9/ 19 , 47 . 37 %) t han t hat in body and fundus ( 0/ 11 , 0 %) ( P = 0 . 0 1) . Conclusion 　M SI may play a cert ain role in gast ric carcinogenesis ,and t he relationship between M SI and clin icop at hological feat ures of GC needs furt her investigation . Key words :micro satellite inst abillity ;gast ric cancer 肝病专科医院 10 年来住院病人疾病谱变化的调查 沈玲 ,赵伟 ,舒伟平 ,袁春蓓 ,高金荣 ,徐永林 (东南大学医学院 附属南京第二医院 ,江苏 南京 　2 10003) [摘要] 目的:了解肝病专科医院 10 年来住院病人疾病谱的变化 ,分析肝癌病例的某些危险因素 ,期望在肝病高危人群中早期 ( ) 诊断肝癌 。方法 :对住院的25 840 例肝病病人进行回顾性调查 。结果 : 1 25 840 例肝病住院病人中男性 占83 . 54 % ,女性 占 ( ) 16 . 46 % ;其中急性肝炎占4 1. 55 % ,慢性肝炎占30 . 62 % ,肝硬化占22 . 08 % ,肝癌 占5 . 75 % 。 2 青年组慢性肝炎比例上升 占 ( ) ( ) 同病种病人的 68. 48 % 5 4 19/ 7 9 13 ,中年组肝硬化