sub-threshold depression and antidepressants use in a community sample searching anxiety and finding bipolar disorder亚阈值焦虑抑郁和抗抑郁药在社区样本中使用搜索,发现双相情感障碍.pdf

Carta et al. BMC Psychiatry 2011, 11:164 /1471-244X/11/164 RESEARCH ARTICLE Open Access Sub-threshold depression and antidepressants use in a community sample: searching anxiety and finding bipolar disorder 1* 2 3 4 5 6 Mauro G Carta , Leonardo Tondo , Matteo Balestrieri , Filippo Caraci , Liliana dell’Osso , Guido Di Sciascio , 7 1,8 1 1 9 Carlo Faravelli , Maria Carolina Hardoy , Maria E Lecca , Maria Francesca Moro , Krishna M Bhat , Massimo Casacchia10 and Filippo Drago4 Abstract Background: To determine the use of antidepressants (ADs) in people with sub-threshold depression (SD); the lifetime prevalence of mania and hypomania in SD and the link between ADs use, bipolarity and anxiety disorders in SD. Methods: Study design: community survey. Study population: samples randomly drawn, after stratification from the adult population of municipal records. Sample size: 4999 people from seven areas within six Italian regions. Tools: Questionnaire on psychotropic drug consumption, prescription; Structured Clinical Interview NP for DSM-IV modified (ANTAS); Hamilton Depression Rating Scale (HAM-D); Mood Disorder Questionnaire (MDQ); Short Form Health Survey (SF-12). SD definition: HAM-D 10 without lifetime diagnosis of Depressive Episode (DE). Results: SD point prevalence is 5.0%. The lifetime prevalence of mania and hypomania episodes in SD is 7.3%. Benzodiazepines (BDZ) consumption in SD is 24.1%, followed by ADs (19.7%). In SD, positive for MDQ and comorbidity with Panic Disorder (PD) or Generalized Anxiety Disorders (GAD) are associated with ADs use, whereas the association