association between striatal subregions and extrastriatal regions in dopamine d1 receptor expression a positron emission tomography study协会之间的纹状体多巴胺d1受体表达的条件和extrastriatal地区一个正电子发射断层扫描研究.pdf

Association between Striatal Subregions and Extrastriatal Regions in Dopamine D1 Receptor Expression: A Positron Emission Tomography Study 1 2 1 1 1 Hironobu Fujiwara , Hiroshi Ito *, Fumitoshi Kodaka , Yasuyuki Kimura , Harumasa Takano , Tetsuya Suhara1 1 Clinical Neuroimaging Team, Molecular Neuroimaging Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan, 2 Biophysics Program, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan Abstract The mesencephalic dopamine (DA) system is the main DA system related to affective and cognitive functions. The system consists of two different cell groups, A9 and A10, which originate from different regions of the midbrain. The striatum is the main input from the midbrain, and is functionally organized into associative, sensorimotor and limbic subdivisions. At present, there have been few studies investigating the associations of DA functions between striatal subdivisions and extrastriatal regions. The aim of this study was to investigate the relationship of DA D receptor (D R) expression between 1 1 striatal subdivisions and extrastriatal regions in humans using positron emission tomography (PET) with voxel-by-voxel whole brain analysis. The PET study was performed on 30 healthy subjects using [11C]SCH23390 to measure D R expression. 1 Parametric images of binding potentials (BPND) were created using the simplif