软膏剂的制备工艺论-广西中医药大学 南宁.docx

?软膏剂的制备? （广西中医药大学 南宁 530022）? 摘要：目的??掌握不同类型基质软膏剂的制备的方法。[1]了解软膏剂质量评定方法。方法 ?采用研和法，融和法和乳化法制备软膏剂。 结果 ??软膏主要对皮肤，粘膜或创面起保护、润滑和局部治疗作用，如消炎、杀菌、防腐、收敛等作用。某些药物透皮吸收后，亦能产生全身治疗作用。可根据药物和基质性质、制备的量及设备条件等适当选用。 结论 [3]油脂性基质软膏为白色，表面细腻光滑；O/W型乳化剂基质软膏为白色，表面细腻光滑；水溶性基质软膏为淡粉色半透明，表面细腻光滑。? 关键词：软膏剂 研和法 融和法 乳化法 基质 Preparation of ointment Huang Huan (Guangxi Medical University, Nanning 530022) Abstract: Objective To understand the different types of matrix method of preparation of ointments. [1] understand ointments quality assessment methods. Methods research and method, integration method and emulsifying ointment prepared. The main results of the ointment on the skin, mucous membranes or wounds from protection, lubrication and topical treatment, such as anti-inflammatory, bactericidal, antiseptic, astringent effects. After percutaneous absorption of certain drugs, can also produce systemic therapeutic effect. According to the nature of the drug and the matrix, selection of the appropriate amount of preparation and equipment conditions. Conclusion [3] oleaginous base ointment is white, fine and smooth surface; O / W emulsifier matrix ointment is white, fine and smooth surface; soluble matrix ointment is pale pink translucent surface smooth and delicate. Keywords: research and legal integration method ointment emulsion method matrix 1.材料和方法? 1.1仪器?? 电磁炉，研磨，软膏板等。 1.2材料?? 水杨酸，白凡士林,羊毛脂,液体石蜡,硬脂酸，单硬脂酸甘油脂，吐温80，甘油，羟甲基纤维素钠，苯甲酸钠，蒸馏水。 2?实验内容? 2.1处方?? 2.1.1??油脂性基质软膏的制备? 水杨酸????1.0g??? 液体石蜡?? 适量???? 凡士林??? 加至20.0g? 2.1.2??O/W型乳化剂基质软膏的制备? 水杨酸?? 2.0g??? 硬脂酸? 4.8g???? 单硬脂酸甘油脂? 2.8g??? 白凡士林? 0.4g? 羊毛脂? 2.0g???? 液体石蜡? 2.4g?? 吐温80? 0.16g???????? 蒸馏水?? 加至40.0g 2.2.1? 取水杨酸置于研钵中，加入适量液体石蜡研成糊状，分次加入凡士林，研匀即得。 2.2.2? 取硬脂酸、单硬脂酸甘油脂、白凡士林和液体石蜡置小烧杯中，于水浴上加热至80摄氏度左右,搅拌使熔化.另取吐温80和计算量蒸馏水置另一个小烧杯,于水浴上加热至约80摄氏度,搅拌均匀.在同温下,将水相以细流加到油相中,并于水浴上不断顺方向搅拌成乳白色半固体状,再在室温下搅拌至近冷凝.取水杨酸置于软膏板上和研钵中,分次加入制得的O/W型乳化剂基质，研匀即得。 3?实