炎琥宁联合西咪替丁治疗婴幼儿轮状病毒肠炎的疗效观察.doc

炎琥宁联合西咪替丁治疗婴幼儿轮状病毒肠炎的疗效观察 　　作者：李波，冯丽琼，陈择岐，王君富 作者单位：佛山市南海区松岗医院儿科,广东 佛山 528234 　　【摘要】 目的：观察炎琥宁联合西咪替丁治疗婴幼儿轮状病毒肠炎的疗效。 方法：对符合婴幼儿轮状病毒肠炎的临床诊断标准的103例患儿随机分为观察组及对照组，观察组51例，对照组52例。两组均予补液，维持水电解质酸碱平衡，微生态疗法(妈咪爱)及肠黏膜保护剂(思密达)等常规治疗。对照组给予病毒唑 10～15 mg/(kg·d)，加入葡萄糖静脉滴注，每天1次，连续3 d。观察组给予炎琥宁10 mg/(kg·d)及西咪替丁10～20 mg/(kg·d)静脉滴注，每天1次，连续3 d。观察两组患儿治疗后退热及止泻时间等疗效。结果：观察组的退热时间、止泻时间均明显短于病毒唑对照组;观察组有效率为92.2%，较对照组的82.7%高，有显著性差异 (P均0.05)。结论：炎琥宁联合西咪替丁治疗婴幼儿轮状病毒肠炎的疗效优于病毒唑。 　　【关键词】 肠炎;病毒;西咪替丁;中草药;儿童 　　Effects of treating infantile rotavirus enteritis with potassium sodium dehydroandroan drographolide succinate and cemitidine 　　LI Bo, FENG Liqiong, CHEN Zeqi, WANG Junfu 　　(Department of Pediatrics, Songgang Hospital of Nanhai District， Fushan City, Fushan 528234,China ) 　　[ABSTRACT] Objective: To investigate the effects of treating infantile rotavirus enteritis with potassium sodium dehydroandroan drographolide succinate and cemitidine. Methods: One hundred and three infantile patients diagnosed as rotavirus enteritis according to clinical diagnostic criteria were divided randomly into trial group(n=51) and control group(n=52). On the base of treated all patients routinely with replenishment of liquid, maintaining balance of waterelectrolyte, acid and base, undergoing therapy of microorganisms with medial- vita and protection of gastrointestinal mucosa with smecta; patients in control group treated with ribavirin 10～15 mg/(kg·d) diluted with glucose solution intravenously, once a day for 3 days. Patients in trial group treated with potassium sodium dehydroandroan drographolide succinate 10 mg/(kg·d) and cimetidine 10～20 mg/(kg·d) intravenously, once a day for 3 days. Effects of abating fever and anti-diarrhea were observed. Results: The time of fever ceasing and diarrhea control in trial group was shorter than that in control group; the effectuate rates of the trial group and control group were 92.2%and 82.7% respectively, compared them, there were significant differences(all P