sublethal rna oxidation as a mechanism for neurodegenerative disease亚致死的rna氧化作为神经退行性疾病的机制.pdf

Int. J. Mol. Sci. 2008, 9, 789-806; DOI: 10.3390/ijms9050789 OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /ijms Review Sublethal RNA Oxidation as a Mechanism for Neurodegenerative Disease Rudy J. Castellani 1,*, Akihiko Nunomura 2, Raj K. Rolston 3, Paula I. Moreira 4, Atsushi Takeda 5, George Perry 3,6 and Mark A. Smith 3,* 1 Department of Pathology, University of Maryland, Baltimore, Maryland, USA 2 Department of Neuropsychiatry, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Yamanashi, Japan 3 Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA 4 Center for Neuroscience and Cell Biology of Coimbra, University of Coimbra, Coimbra, Portugal 5 Department of Neurology, Tohoku University School of Medicine, Sendai, Japan 6 College of Sciences, University of Texas at San Antonio, San Antonio, Texas, USA E-Mails: rcastellani@ (R. J. C.); anunomura@yamanashi.ac.jp (A. N.); rajrolst@ (R. K. R.); venta@ci.uc.pt (P. I. M.); atakeda@em.neurol.med.tohoku.ac.jp (A. T.); george.perry@ (G. P.); mark.smith@ (M. A. S.) * Authors to whom correspondence should be addressed; E-mail: rcastellani@; Tel.: +1-410-328-5422 (R.J.C.) and E-mail: mark.smith@; Tel.: +1-216-368-3670 (M.A.S.) Received: 25 April 2008; in revised form: 15 May 2008 / Accepted: 16 May 2008 / Published: 20 May 2008 Abstract: Although cellular RNA is subjected to the same oxidative insults as DNA and