中药提取物FAC的抗肿瘤作用及其机制的初步研究.pdf

24 6 Vol.24 No.6 2005 12 Chinese Wild P lant R esources Dec. 2005 FAC 韦翠萍, 张 熠,顾振纶 (, , 215007) :探讨中药提取物FAC 对H 肝癌实体瘤的作用及其机制: 制备人肝癌H 荷瘤 鼠模型,观察 22 22 中药提取物FAC对H 肝癌实体瘤的抑制作用及其对荷瘤 鼠免疫器官存活期巨噬细胞吞噬功能淋巴细胞转 22 化功能的影响: 鼠灌服中药提取物FAC 10 d后, 中大剂量组抑瘤作用显著, 荷瘤 鼠存活期明显延长,反 映免疫功能的胸腺指数和脾指数显著增加,巨噬细胞吞噬功能和淋巴细胞转化功能明显增强结论: 中药提取物 FAC 可抑制人肝癌H 实体瘤的生长, 并能提高荷瘤 鼠的免疫功能提示中药提取物FAC 可能通过增强机体免 22 疫功能而发挥抗肿瘤作用 中药提取物FAC;H 肝癌; 抗肿瘤作用;免疫功能 22 Preliminary Study of FAC on the Antitumor Effect and Its Mechanism ei Cuiping,Zhang Yi,GuZhenlun (Department of Pharmacology of Medical College of SuchouUniversity,Institute of ChineseMeterialMedica,Suzhou 215007,China) Abstract Objective:To study theantitumor activityandimmunemodulationonextract of Traditional Chinese Medicine. Methods:Theexperiment animalmodel onH mousewere established.The inhibitory effect ofFAC 22 onmicebearingH22,thelife- spanofmicebearingH22 andthethymusindex andspleenindex wereobserved. meanwhile the effect of FAConimmunefunctionsuchasphagocytosisof macrophages andlymphocytetransfor- mationwere investigatedtoo.Results:Aftertreatmentwith 10days,middleandhigh concentrationmarkedly in- hibit H growth ,and prolong the life- spanof mice bearing H markedly ;FAC can also markedly enhance 22 22 immunefunction. Conclusion:FAChas the antitumor effect of H and the effect of immunemodulation .The 22 resultssugge