psoriasis银屑病().ppt

How is it treated? Treatment is aimed to control symptoms. Non-infectious , relapsing, need for long-term therpy Treatment decisions in patients with psoriasis are made on an individual basis 2% 2%—10% 10% Topical therapy Topical corticosteroids Popular and effective Especially on their withdrawal Vitamin D analogues they inhibit cell proliferation and stimulate keratinocyte differentiation Skin irritation may be a problem Hypercalcaemia Retinoids 0.025% and 0.1% Keratolytics preparations 5% salicylic acid ointment (palms soles) 3% salicylic acid cream Coal tar preparations Dithranol(Anthralin) Shampoo Systemic therapy Systemic therapy Retinoids Corticosteroids Antibiotics Immunosuppressant Biologic agents Retinoids Corticosteroids Antibiotics Immunosuppressant Methotrexate severe psoriasis Monitor liver, kidney and bone marrow function teratogen Immunosuppressant Ciclosporin Inhibiting T-lymphocyte activation and interleukin-2 production Nephrotoxicity Risk of skin cancers or lymphoma Biologic agents Other therapy PUVA、UVB drug bath Chinese drugs prevention Course Advance Still Recession Advance Koebner phenomenon. Still No new rash Recession Rash gradually reduced psoriasis arthropathica psoriasis arthropathica psoriasis arthropathica psoriasis pustulosa withdrawal of steroids or immunodepressant, or potent stimulation drug Generalized and localized forms Generalized pustular acute sheets , small, sterile yellowish pustules develop on an erythematous background fever Palmoplantar pustulosis Localized on the palms or soles，symmetry Characterized by yellow to brown-coloured sterile pustules Nail erythrodermic psoriasis withdrawal of steroids, or an intercurrent drug eruption the specific features of psoriasis are lose Histopathology Histopathology hyperkeratosis parakeratosis granular layer acanthosis lengthened rete ridges Histopathology Capillaries are dilated in the papillary dermis Histopathology Microabscesses