苏州大学《免疫学》G卷.doc

苏州大学《免疫学》G卷 考试形式 闭卷 院系 ___________ 年级 ____________ 专业 ____________ 学号 ___________ 姓名 ____________ 成绩 ____________ A. explain terms (8’ * 5 ) 1. epitope 3. CDR 5. AICD 2. TCR / CD3 complex 4. TAA 6. Th 7. clonal selection 8. positive selection of T lymphocytes Long questions (20’ * 3) 1. Please explain the definition, functions of complement system and compare both complement activation pathways. 2. It was reported that a girl named Nita Sekhri who was allergic to garbanzos was killed by inhaling the fumes from a pot of cooking garbanzo beans. Please explain the mechanism by the theory the hypersensitivity. 3. please describe 2-signal theory for T cell activation. Immunology (G) answers A.small questions (concept explanation) 1. Idiotype: These are unique antigenic determinant associated with antigen binding sites of antibodies and are the results of the different amino acid sequences which determine their specificities. Variation in the variable domain, particularly the hypervariable regions, produces idiotypes. These determine the binding specificity of the antigen-binding site. 2. CDRs: At the amino acid level, the variable region of antibody is comprised of three regions of extreme variability (hyervarible region). They are called complementarity-determining regions, or CDRs. Interspersed among the CDRs are framework regions (FRs) which are less variable and more evolutionarily conserved. At the three-dimensional level, the three CDRs of each chain converge to form a combining site which recognize the antigenic determinant (epitope). 3. cytokines Definition: Cytokines are small molecules, secreted by cells in response to a stimulus. Function: As a group, cytokines induce growth, differentiation, chemotaxis, activation and/or enhanced cytotoxity. They are used for strengthening communications between cells. 4.ADCC ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICIT