脂肪酸代谢与肿瘤.pptx

Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4;Background-脂肪酸代谢;Background-花生四烯酸的代谢;Background-cAMP途径;Background;Background; Src homology 2 (SH2)-containing protein tyrosine phosphatase 2 (SHP2), encoded by the human PTPN11 gene, is a protein tyrosine phosphatase (PTP) and a member of the nonreceptor PTP subfamily.SHP2 is an ubiquitously expressed nontransmembrane PTP that plays an essential role in many organisms, from lower eukaryotes to mammals. SHP2 is phosphorylated in vitro by cAMP-dependent protein kinase (PKA) and in vivo by ACTH in bovine adrenal cells. However, no evidence is available on the relationship between this activation and the steroidogenic function of the cell. ;Objective:;Conclusion:;results;results;results;results;results;results;results;results;results;Conclusion:;highlights the first time that SHP2 has an obligatory role in steroid production by a mouse Leydig cell line, regulating the expression of ACSL4 protein. Our results are in agreement with the only report published on the subject—SHP2 is activated through a cAMP-dependent pathway Shortage WB实验效果不佳； 未涉及到ACSL4的磷酸化研究。