synthetic biomimetic membranes and their sensor applications合成的仿生膜及其传感器的应用.pdf

Sensors 2012, 12, 9530-9550; doi:10.3390/s120709530 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Review Synthetic Biomimetic Membranes and Their Sensor Applications Young-Rok Kim 1, Sungho Jung 2, Hyunil Ryu 2, Yeong-Eun Yoo 3, Sun Min Kim 4,5 and Tae-Joon Jeon 2,5,* 1 Institute of Life Sciences and Resources Department of Food Science and Biotechnology, Kyung Hee University, Yongin 446-701, Korea; E-Mail: youngkim@khu.ac.kr 2 Department of Biological Engineering, Inha University, Incheon 402-751, Korea; E-Mails: sunghomail@ (S.J.); hyunil.ryu@ (H.R.) 3 Nano-Mechanical Systems Research Division, Korea Institute of Machinery and Materials, Daejeon 305-343, Korea; E-Mail: yeyoo@kimm.re.kr 4 Department of Mechanical Engineering, Inha University, Incheon 402-751, Korea; E-Mail: sunmk@inha.ac.kr 5 Biohybrid Systems Research Center, Inha University, Incheon 402-751, Korea * Author to whom correspondence should be addressed; E-Mail: tjjeon@inha.ac.kr; Tel.: +82-32-860-7511; Fax: +82-32-872-4046. Received: 9 May 2012; in revised form: 5 June 2012 / Accepted: 16 June 2012 / Published: 11 July 2012 Abstract: Synthetic biomimetic membranes provide biological environments to membrane proteins. By exploiting the central roles of biological membranes, it is possible to devise biosensors, drug delivery systems, and nanocontainers using a biomimetic membrane system integrated with functional proteins. Biomimetic membranes can be created with synthetic lipids or block copolymers. These amphiphili