the impact of study design and diagnostic approach in a large multi-centre adhd study part 2 dimensional measures of psychopathology and intelligence研究设计和诊断方法的影响在一个大型的多中心adhd研究精神病理学的二维测量部分和智慧.pdf

Müller et al. BMC Psychiatry 2011, 11:55 /1471-244X/11/55 RESEARCH ARTICLE Open Access The impact of study design and diagnostic approach in a large multi-centre ADHD study: Part 2: Dimensional measures of psychopathology and intelligence 1,2* 3 4,12 5 6 6 Ueli C Müller , Philip Asherson , Tobias Banaschewski , Jan K Buitelaar , Richard P Ebstein , Jaques Eisenberg , 7 8 9 10 11 12 Michael Gill , Iris Manor , Ana Miranda , Robert D Oades , Herbert Roeyers , Aribert Rothenberger , Joseph A Sergeant 13, Edmund JS Sonuga-Barke11,14, Margaret Thompson14, Stephen V Faraone15 and Hans-Christoph Steinhausen1,16,17 Abstract Background: The International Multi-centre ADHD Genetics (IMAGE) project with 11 participating centres from 7 European countries and Israel has collected a large behavioural and genetic database for present and future research. Behavioural data were collected from 1068 probands with ADHD and 1446 unselected siblings. The aim was to describe and analyse questionnaire data and IQ measures from all probands and siblings. In particular, to investigate the influence of age, gender, family status (proband vs. sibling), informant, and centres on sample homogeneity in psychopathological measures. Methods: Conners’ Questionnaires, Strengths and Difficulties Questionnaires, and Wechsler Intelligence Scores were used to describe the phenotype of the sample. Data were analysed by use of robust statistical multi-way procedures. Results: Besides main effects of age, gender, informant, and centre, there were considerable interaction effects on questi