the design, development, and evaluation of a prototypic, prosthetic venous valve设计、开发和评价被,假体静脉瓣膜.pdf

BioMedical Engineering OnLine BioMed Central Research Open Access The design, development, and evaluation of a prototypic, prosthetic venous valve Matt T Oberdier and Stanley E Rittgers* Address: Department of Biomedical Engineering, The University of Akron, Akron, OH 44325, USA Email: Matt T Oberdier - oberdiermt@; Stanley E Rittgers* - srittgers@ * Corresponding author Published: 19 September 2008 Received: 6 June 2008 Accepted: 19 September 2008 BioMedical Engineering OnLine 2008, 7:25 doi:10.1186/1475-925X-7-25 This article is available from: /content/7/1/25 © 2008 Oberdier and Rittgers; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Chronic venous insufficiency is a serious disease for which there is no clearly successful surgical treatment. Availability of a proven prosthetic vein valve could provide such an option by reducing venous reflux while permitting normal antegrade flow. Methods: A new prosthetic vein valve design has been developed which mimics the function of a natural valve by ensuring complete closure of the leaflets with minimal obstruction for antegrade flow. A 2:1 mock-up of the device was tested to evaluate its ability to prevent regurgitation and several key modifications w