单唾液酸四己糖神经节苷脂临床应用研究进展.pdf

Food and Drug 2012 14 05 207 250012 GM1 GM1 R741 A 1672-979X2012 05-0207-04 Progress on Clinical Application of Monosialotetrahexosyl Ganglioside Gong Lei, Zang Heng-chang (School of Pharmaceutical Sciences Shandong University Jinan 250012 China) Abstract: Gangliosides constitute a group of glycosphingolipids that are components of most vertebrate cell membranes and play an important role in nervous system. Monosialotetrahexosyl ganglioside(GM1)is studied and used the most intensively so far. In this review, we discuss the main clinical application with an emphasis on HIE CNS problemsneurodegenerative diseases and peripheral neuropathy. Key Words: monosialotetrahexosyl ganglioside; clinical application; adverse reaction ganglioside [1] 1 hypoxic-ischemic encephalopathy GM1 GM1 1 HIE 142 11 [4] GM1 HIE [5]102HIE HIE [2] GM1GM1710 d 20NBNA [6] 60HIE GM1 -9 MMP-9 GM1 MMP-9GM1 1 GM1[3] P0.01 GM1 HIEGM1 GM1 NSE 2012-02-07 1979- *E-mail:zanghcw@126.com Food and Drug 2012 14 05 208