周二下午stroke narration中风药物干预预防.pdf

Pharmacologic Intervention and Prophylaxis of Stroke Dr. Fran Gengo Director Neuropharmacology Dent Neurologic Institute Associate Professor Neurology Pharmacy Schools of Medicine Pharmacy University at Buffalo Copyright ©: Reproduction of these slides is prohibited without permission of the author Objectives: 1. To def ransient ischemic attack (TIA), completed stroke, and stroke-in evolution. 2. To ex in the etiology and pathophysiology of stroke and circumstances leading to irreversible brain death and the time window in which intervention may be helpful. 3. To list the signs and symptoms of, and risk factors for, a stroke. 4. To ex in the differences, advantages and disadvantages of various anti et drugs for secondary stroke prevention. The brain has one of the highest metabolic rates of all organs. Although it is 2% of the body weight it receives 17% of the total cardiac output and consumes 20% of the oxygen utilized by the entire body. Blood flow through the brain is 750 ml/minute. The vertebro-basilar system s each level of the brain stem and cerebellum. Medulla •anterior spinal and vertebral arteries •Posterior inferior cerebellar artery (PICA) Pons •basilar artery Midbrain: •posterior cerebral, posterior communicating [C] Stroke following chiropractic manipulation JS Jeret, M Bluth - Cerebrovascular Diseases, 2002 - The Carotid Circulation Lacunar 19% Thromboembolic 6% SAH 13% Embolic 14% Hemorrhagic