中药学专业关于丹参酮Ⅱa磺酸钠微量杂质的分离与结构鉴定毕业论文.doc

中国药科大学 本 科 毕 业 论 文 论文题目 丹参酮Ⅱa磺酸钠微量杂质的分离与结构鉴定 英文题目 Separation Of Microimpurity And Identification Of Sodium Tanshinone Ⅱa Sulfonate 专 业 中药学 院 部 中药学院 学 号 姓 名 指导教师 课 题 完成场所 中药学院天然药物化学教研室 论文工作时间： 2009 年 3月 至 2009年 6月 丹参酮IIa磺酸钠微量杂质的分离及结构鉴定摘要参考文献致谢丹参酮IIa磺酸钠微量杂质的分离及结构鉴定： Separation of Microimpurity and Identification of Sodium Tanshinone IIa Sulfonate Abstract: Salvia miltiorrhiza is one of the most important tradition Chinese medicinal materials that possess the function of both promoting blood flow and removing blood stasis with anti-coronary artery disease. The consumed quantity only in the aspect of injection has been exceeded 2 billion dosages every year. However, because the undetermined active ingredients and relaxed index of quality control induced the instable effects of clinic traterment, and, moreover, usually adverse functions, which lead salvia miltiorrhiza unable to accommodate requirement of contemporary Chinese medicinal materials melting world. Sulfotanshinone sodium is asodium chloride of water-solubility after sulfonating tanshinone IIa of liposolubility active ingredien tabstraeted in salvia miltiorrhiza.It is an effective medicine of angiocardiopathy to treat coronary artery disease, anginacordis，and myocardial infarction.The amount of clincal utilization continuous. increasing with the high proportion of patients of angiocardiopathy induces raw material resource of salvia miltiorrhiza insufficient in China. So it becomes an extensive focus point in fharmaceutical factory that sufficient utilize and cut down uymost dissipation resource of salvia miltiorrhiza. Keywords:1-Hydroxy-Tanshinone IIa sulfonate ; sodium tanshinoneⅡA sulphonate(STS);tanshinoneIIa;separation;identification 前言 丹参是活血化淤的传统中药，具有良好的抗冠心病等作用。其制剂及复方制剂品种繁多，仅注射剂的年使用量就达20亿支以上，但多数产品有效成分不