1柑橘属中生物碱辛弗林生理活性的研究进展_张文娟_陶缘_王亚军_陈健初.pdf

网络出版时间：2013-08-12 13:22 网络出版地址：/kcms/detail/11.1759.TS1322.012.html 柑橘属中生物碱辛弗林生理活性的研究进展 张文娟，陶 缘，王亚军，陈健初； （浙江大学食品科学与营养系，浙江杭州 310058） 摘 要 柑橘中含有黄酮类化合物、类柠檬苦素、维生素、类胡萝卜素、有机酸、生物碱等多 种生物活性成分，其中主要的生物碱有辛弗林，章鱼胺，酪胺。辛弗林是芸香科植物酸橙枳 实提取物中的有效成分。2004 年，美国FDA 禁止在减肥产品中添加麻黄碱。由于辛弗林和 麻黄碱在化学结构类似，副作用较小，因此成为其替代品，具有广泛的应用市场。辛弗林减 肥作用机理是由于刺激脂肪分解，提高代谢速率和促进脂肪氧化，静脉注射辛弗林会对健康 人的血压、支气管、心血管及糖尿病模型小鼠的肝脏抗氧化体系产生影响，含有辛弗林的膳 食补充剂中可能还含其他物质（如咖啡因等神经兴奋类化合物），可能增加副作用的风险， 影响健康。针对枳实提取物的广泛应用，本文对其主要成分辛弗林的化学性质和生理活性进 行综述。 关键词 辛弗林，化学性质，活性研究 Research progress in biological activity of p -synephrine in cirus fruits ZHANG Wen juan, TAO Yuan, WANG Ya-jun, CHEN Jian -chu (Department of Food Science Nutrition ， Zhejiang University ，Zhejiang ，Hangzhou 310058) Abstract Citrus species contain numerous bioactive compounds including flavonoids, limonoids, vitamins, carotenoids, organic acids and amines. Synephrine, octopomine and tyramine are commonly occurring amines in citrus. It is the most abundant active component of extracts from Citrus aurantium L. unripe fruits. Synephrine is structurally is related to endogenous neurotransmitters (epinephrine and norepinephrine) and has gained significant popularity for the treatment of obesity. Moreover, the ban of ephedrine containing substance by Food Drug Administration because of an association with serious adverse health effects seems to have resulted in higher consumption of dietary supplements containing synephrine due to