.新生儿动脉导管未闭的高危因素分析.pdf

中国科技论文在线 # 新生儿动脉导管未闭的高危因素分析 1 2 1 1 1** 屈晓羽 ，周先锋 ，屈艺 ，唐彬秩 ，母得志 （1. 四川大学华西第二医院儿科，成都 610041； 2. 四川大学华西公共卫生学院卫生统计教研室，成都 610041） 摘要： 目的 探讨新生儿动脉导管未闭（patent ductus arteriosus，PDA）的高危因素，为 PDA 的预防提供临床依据。方法 以 50 例 PDA 为病例组，100 例非 PDA 为对照组，采用χ2 检验、t检验或直线相关对两组患儿的临床资料进行分析，采用 Logistic回归分析研究 PDA 的独立高危因素。结果 PDA与胎龄、出生体重呈负相关。PDA 与早产、低出生体重、双胎、 宫内窘迫、羊水粪染、羊水过少、脐带缠绕、1分钟Apgar 评分＜8 分、母孕期感染、母孕 期糖尿病、合并缺氧缺血性脑病、出生时吸氧治疗有关。其中，出生时吸氧治疗为保护因素。 宫内窘迫、羊水粪染、羊水过少、脐带缠绕、1分钟Apgar 评分＜8 分、母孕期感染、合并 缺氧缺血性脑病是新生儿PDA的独立高危因素。结论 避免母孕期感染、早产、低出生体重、 缺氧的发生，有利于减少PDA的发生。 关键词：动脉导管未闭；新生儿；高危因素 Risk factors for patent ductus arteriosus in neonates 1 2 1 1 1 Qu Xiaoyu , Zhou Xianfeng , Qu Yi , Tang Bingzhi , Mu Dezhi (1. Department of Pediatrics, West China Second University Hospital, Sichuan University, ChengDu 610041; 2. Health Statistics Department, West China School of Public Health, Sichuan University, ChengDu 610041) Abstract: Objective To identify the risk factors for patent ductus arteriosus （PDA ）. Methods 50 infants with PDA were cases and 100 infants without PDA were controls. Chi-square test, Student ’s t test or linear correlation were used to analyze the clinical data. The Logistic regression analysis was used to investigate the independent risk factors for PDA. Results PDA was negative correlation with gestation age and birth weight. The development of PDA was associated with premature, low birth weight, twins, fetal distress, meconium-stained amniotic fluid, oligohydramnios, cord entanglement, 1 minute Apgar score ＜8, maternal infection, maternal diabetes, hypoxic-i