antibacterial activity of polymer coated cerium oxide nanoparticles聚合物包覆的纳米氧化铈的抗菌活性.pdf

Antibacterial Activity of Polymer Coated Cerium Oxide Nanoparticles 1 1 1 2 2 3 Vishal Shah *, Shreya Shah , Hirsh Shah , Fred J. Rispoli , Kevin T. McDonnell , Selam Workeneh , 4¤ 4 4 Ajay Karakoti , Amit Kumar , Sudipta Seal * 1 Department of Biology, Dowling College, Oakdake, New York, United States of America, 2 Department of Mathematics and Computer Science, Dowling College, Oakdale, New York, United States of America, 3 Department of Biology, Southern University at New Orleans, New Orleans, Louisiana, United States of America, 4 Advanced Materials Processing Analysis Center, Nanoscience Technology Center, Mechanical Materials Aerospace Eng, University of Central Florida, Orlando, Florida, United States of America Abstract Cerium oxide nanoparticles have found numerous applications in the biomedical industry due to their strong antioxidant properties. In the current study, we report the influence of nine different physical and chemical parameters: pH, aeration and, concentrations of MgSO , CaCl , KCl, natural organic matter, fructose, nanoparticles and Escherichia coli, on the 4 2 antibacterial activity of dextran coated cerium oxide nanoparticles. A least-squares quadratic regression model was developed to understand the collective influence of the tested parameters on the anti-bacterial activity and subsequently a computer-based, interactive visualization tool was developed. The visualization allows us to elucidate the effect of each of the parameters in combination with other parameters, on the antibacterial activity of nanoparticles. The results indicat