st segment depression the possible role of global repolarization dynamicsst段萧条全球复极化动力学的可能作用.pdf

BioMedical Engineering OnLine BioMed Central Research Open Access ST segment depression: the possible role of global repolarization dynamics Bruce Hopenfeld* Address: Angel Medical Systems, 1 Sheila Drive, Tinton Falls, New Jersey 07724, USA Email: Bruce Hopenfeld* - brhopenfeld@ * Corresponding author Published: 9 February 2007 Received: 12 December 2006 Accepted: 9 February 2007 BioMedical Engineering OnLine 2007, 6:6 doi:10.1186/1475-925X-6-6 This article is available from: /content/6/1/6 © 2007 Hopenfeld; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: At least some clinical data suggests that, regardless of which major coronary artery is narrowed, the early ST segment body surface pattern is characterized by a minimum near precordial lead V5 and a broad area of left precordial negative potentials. Some clinical data also suggests that late ST segment potentials can localize an ischemic heart region. Objective: A computer model of a heart/torso system was implemented to study the relationship between transmembrane potentials throughout the heart and clinically observed body surface potential patterns during the early and late ST segments in ischemic patients.