人脑胶质瘤中miR-125b和Gli1的表达及临床意义.pdf

．167． 25b和Gli 人脑胶质瘤中miR．1 1的表达及临床意义 顾文韬，顾士欣，寿佳俊，车晓明 (复旦大学附属华山医院神经外科200040) 关键词 miR．125b；胶质瘤；Glil；预后 摘要目的探讨miR．125b在胶质瘤中的表达及其与Glil的关系。方法收集不同病理级别胶质瘤标本25例，以荧 果 组织(1．OOO)略高，肿瘤的恶性程度与Gl订表达水平呈负相关，闾变星形细胞瘤与胶质母细胞瘤比较，差异有统计学意 质瘤的发生、发展密切相关。 andClinic ofmiR—125bandGⅡ1inHumanGliomas Expression Signmcance GU耽玎一加D，GU。妨f《f聍， 繇矽U觑靓C厅暇簿∞一删堙DepartnlentofNeurosurge巧，HuashanHospital，FudanUniVersi移，Shanghai 200040、China l(EYWoIUD miR一125b；glioma；GUl；prognosis ABSTRACTmm To me alldcliIlical oflIliR-125b卸dGl订iIlhuman allalyzeexpression si蛳ficaIlce 2lioma The ofmiR一125bandGlilwefedetected fluorescencePCR samples．Methodsexpressions by quantitative in25 tlle be觚een ofmiR．125baIldGl订andⅡ1e and 91ioma relationship samples．Tlle expressions mali印ancy ofthe were ①The leVeIsofmiR-125bindifferent prognosisgliomasanalyzed．Resultsexpression groups of gliomas[as仃ocytoma(0．754±0．085)，an印lasticas仃ocytom(0．545±0．075)aIld glioblastoma(0．340± 0．056)]were tono蛐a1brain werealso con．elated dow珈．egulatedcompared tissue(1．000)，whichnegatively withtI腿or levelsofGliliIldi虢rent mali印ancy．②rnleeXpression groupsofgliom豁【嬲仃oc如咖a(1．034± 1 O．093)，aIl印1asticas们cytoma(1．203±0．1 3)and百iobl嬲toma(1．578±O．087)】wereupre鲥atedcompared tonomalbraill werealsocorrelatedwitll tumor withthe tissue(1．000)，which