zinc or multiple micronutrient supplementation to reduce diarrhea and respiratory disease in south african children a randomized controlled trial锌或多个微量营养素补充减少腹泻和呼吸道疾病在南非儿童随机对照试验.pdf

Zinc or Multiple Micronutrient Supplementation to Reduce Diarrhea and Respiratory Disease in South African Children: A Randomized Controlled Trial 1 2 3 4 5 6,7 Kany-Kany Angelique Luabeya , Nontobeko Mpontshane , Malanie Mackay , Honorine Ward , Inga Elson , Meera Chhagan , Andrew 8 9 10 Tomkins , Jan Van den Broeck , Michael L. Bennish * 1 Africa Centre for Health and Population Studies, University of KwaZulu Natal, Somkhele, South Africa, 2 Church of Scotland Hospital, Tugela Ferry, South Africa, 3 Department of Medical Microbiology, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa, 4 Division of Geographic Medicine and Infectious Diseases, Tufts-New England Medical Centre, Boston, Massachusetts, United States of America, 5 Department of Chemical Pathology, University of KwaZulu-Natal, Durban, South Africa, 6 Department of Paediatrics and Child Health, University of KwaZulu-Natal, Durban, South Africa, 7 Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, United States of America, 8 Centre for International Child Health, University of London, London, United Kingdom, 9 Tropical Medicine Research Institute, University of the West Indies, Kingston, Jamaica, 10 Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom Background. Prophylactic zinc supplementation has been shown to reduce diarrhea and respiratory illness in children in many developing countries, but its efficacy in children in Africa is uncertain. Objective. To determine if zinc, or zinc plus multiple micronutrients, reduces diarrhea and respiratory disease prevalence. Design. Randomized,