加味六君子汤治疗肾性贫血4000-实用中西医结合临床.DOC

加味香砂六君子汤对早中期肾性贫血患者血常规及血生化指标水平的影响 李玉霞1 张萍2 1甘肃省定西市人民医院肾病科743000；2甘肃省定西市第二人民医院急诊科 743000） 摘要：目的探讨重组人促红素联合加味香砂六君子汤在早中期肾性贫血患者中的临床应用价值。方法选取102例早中期肾性贫血患者为研究对象采用随机数字表法分成联合组（A组51）和对照组（B组51）两组。A组则采用皮下注射重组人促红素联合口服加味香砂六君子汤方案，B组予以皮下注射重组人促红素方案。比对两组患者治疗前后相关血常规、生化指标变化差异；行为期3个月随访，分析两组患者促红素总体用量、不良反应发生情况及复发情况差异。结果治疗后两组患者RBC、Hb、Hct等血常规指标均较治疗前显著提高，BUN、Sr、Cys C、CRP等生化指标则较治疗前显著降低（P0.05）；其中A组患者各指标改善幅度均大于B组（P0.05）；A组促红素使用总剂量为（56 716.231 943.12） IU，显著低于B组的（82 346.262 153.12） IU，差异具有统计学意义（P0.05）；在为期3个月的随访中，A组不良反应发生率为7.8%，复发率为3.9%，均显著低于B组的23.5%和15.7%（P0.05）。结论对早中期肾性贫血患者予以重组人促红素+加味香砂六君汤联合治疗方案，疗效确切，可有效促进其红细胞生长、肾功能改善，值得临床推广。 关键词：肾性贫血；早中期；加味香砂六君子汤；血常规；血生化he Clinical Application Value of Recombinant Human Erythropoietin Combined with Additive Xiangshaliujunzi Decoction in Patients with Renal Anemia at Early and Middle Stage LI Yu-xia1, ZHANG Ping2 (1Department of Nephropathy, the People’s Hospital of Dingxi City, Gansu743000; 2Department of Emergency, the Second People’s Hospital of Dingxi City, Gansu743000) Abstract: Objective: To explore the clinical application value of recombinant human erythropoietin combined with additive Xiangshaliujunzi decoction in patients with renal anemia at early and middle stage. Methods: 102 Patients with renal anemia at early and middle stage were selected as the research objects. According to the random number table method, the objects were divided into the combined group (group A, n=51) and the control group (group B, n=51). The group B were treated with subcutaneous injection of recombinant human erythropoietin (RH) scheme while the group A were treated with subcutaneous injection of recombinant human erythropoietin (RH) combined with oral additive Xiangshaliujunzi decoction scheme. The changes of blood routine and biochemical indexes in the two groups were compared before and after the treatment. With 3 months of follow-up during the behavior phase, the differences in total dosage of erythropoietin, occurrence and recurrence of adverse reactions were analyzed.