医学免疫学 免疫耐受与自身免疫病.ppt

* Tolerance to soluble antigens: A state of tolerance to a variety of T-dependent and T-independent antigens has been achieved in various experimental models. Based on these observations it is clear that a number of factors determine whether an antigen will stimulate an immune response or tolerance (Table 1). * FasL on one T cell may engage Fas either on the same cell or on another cell. * Tolerance to soluble antigens: A state of tolerance to a variety of T-dependent and T-independent antigens has been achieved in various experimental models. Based on these observations it is clear that a number of factors determine whether an antigen will stimulate an immune response or tolerance (Table 1). * Tolerance to soluble antigens: A state of tolerance to a variety of T-dependent and T-independent antigens has been achieved in various experimental models. Based on these observations it is clear that a number of factors determine whether an antigen will stimulate an immune response or tolerance (Table 1). * 口服抗原，经胃肠道诱导小肠派氏集合淋巴结及小肠固有层B细胞产生分泌型IgA，形成黏膜免疫，但却导致全身的免疫耐受。 * Tolerance to soluble antigens: A state of tolerance to a variety of T-dependent and T-independent antigens has been achieved in various experimental models. Based on these observations it is clear that a number of factors determine whether an antigen will stimulate an immune response or tolerance (Table 1). * Tolerance to soluble antigens: A state of tolerance to a variety of T-dependent and T-independent antigens has been achieved in various experimental models. Based on these observations it is clear that a number of factors determine whether an antigen will stimulate an immune response or tolerance (Table 1). * 甲亢性突眼是发生甲亢的时候出现的一种最典型、最常见的症状， 甲亢突眼主要是甲状腺激素的过量作用导致交感神经兴奋而使得眼外肌和提上睑肌张力增高。 * 关节囊炎症 关节滑膜炎症 软骨破坏 * Boutonniere 纽扣花 Ulnar deviation of metacarpophalangeal jounts 掌指尺骨偏移 * 正常情况下，自身应答T 细胞与相应组织特异性抗原并存，但并不引发AID。 原因是，CD4+T细胞只识别由MHC II类分子提呈的抗原，而生理状态下， MHCII类榧子严格的限制性的分布于专职的APC。这意味着大多数组织特异性抗原不会以很高