case series of fertility treatment in hiv-discordant couples (male positive, female negative) the ontario experience生育治疗的病例分析hiv-discordant夫妇(男性积极、女性消极的)安大略的经验.pdf

Case Series of Fertility Treatment in HIV-Discordant Couples (Male Positive, Female Negative): The Ontario Experience 1 2,3 2,3 4 3,5 Trent Newmeyer *, Sandy N. Tecimer , Denise Jaworsky , Steven Chihrin , Kevin Gough , Anita 3,6 7 2 2,3,5 Rachlis , James Martin , Saira Mohammed , Mona R. Loutfy 1 Brock University, St. Catharines, Ontario, Canada, 2 Women’s College Research Institute, Women’s College Hospital, Toronto, Ontario, Canada, 3 University of Toronto, Toronto, Ontario, Canada, 4 University of Western Ontario, London, Ontario, Canada, 5 St. Michael’s Hospital, Toronto, Ontario, Canada, 6 Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada, 7 Southern Ontario Fertility Technologies, London, Ontario, Canada Abstract The success of combination antiretroviral therapies for the treatment of human immunodeficiency virus (HIV) has resulted in prolonged life expectancy (over 40 years from diagnosis) and an improved quality of life for people living with HIV. The risk of vertical HIV transmission during pregnancy has been reduced to less than 1%. As a result of these breakthroughs and as many of these individuals are of reproductive age, fertility issues are becoming increasingly important for this population. One population in which conception planning and reduction of horizontal HIV transmission warrants further research is HIV- discordant couples where the male partner is HIV-positive and the female partner is HIV-negative. Sperm washing is a technique carried out in a fertility clinic that separates HIV from the seminal fluid. Although sperm washing followed by intrauterine insemination signifi