腺苷A2A受体和多巴胺D2受体在小鼠形觉剥夺性近视中的作用研究的中期报告.docx

腺苷A2A受体和多巴胺D2受体在小鼠形觉剥夺性近视中的作用研究的中期报告 摘要： 随着电子产品的广泛使用，近视问题越来越受到关注。本研究旨在探讨腺苷A2A受体和多巴胺D2受体在小鼠形觉剥夺性近视（FD-MS）中的作用。本研究通过FD-MS模型建立，以及激动剂/拮抗剂的注射，观察小鼠的眼轴长度、视网膜厚度以及视网膜细胞密度等指标，分析了腺苷A2A受体和多巴胺D2受体的作用机制。研究表明，激活腺苷A2A受体或拮抗多巴胺D2受体能够减缓FD-MS的发展，而拮抗腺苷A2A受体或激活多巴胺D2受体则具有相反的作用。此外，双重注射能够提高疗效，同时减少副作用。因此，这些结果表明，腺苷A2A受体和多巴胺D2受体在FD-MS中具有重要的调节作用，可以为相关药物的研发提供一定的参考。 关键词：腺苷A2A受体；多巴胺D2受体；形觉剥夺性近视；小鼠；眼轴长度；视网膜厚度；视网膜细胞密度 Abstract: With the widespread use of electronic products, myopia has become an increasingly concerning issue. This study aims to investigate the roles of adenosine A2A receptor and dopamine D2 receptor in form deprivation-induced myopia (FD-MS) in mice. Through the establishment of the FD-MS model, as well as injections of agonists/antagonists, the researchers monitored indicators such as eye axis length, retinal thickness, and retinal cell density in mice and analyzed the mechanisms of action of adenosine A2A receptor and dopamine D2 receptor. The study found that activating the adenosine A2A receptor or antagonizing the dopamine D2 receptor can slow the development of FD-MS, while antagonizing the adenosine A2A receptor or activating the dopamine D2 receptor has the opposite effect. In addition, dual injections can improve efficacy while reducing side effects. Therefore, these results suggest that adenosine A2A receptor and dopamine D2 receptor have important regulatory roles in FD-MS and can provide a reference for relevant drug development. Keywords: adenosine A2A receptor; dopamine D2 receptor; form deprivation-induced myopia; mice; eye axis length; retinal thickness; retinal cell density