肿瘤生物学与转化医学.ppt

Then the anti-metastasis and recurrence effect of LICARTIN was determined in the post-orthotopic liver transplantation (OLT) HCC patients. Our initial results showed that LICARTIN significantly decreased recurrence rate and increased survival rate of HCC patients, compared with untreated control group. So LICARTIN is a promising new anti-metastasis and recurrence agent for treating HCC. Problems of Cancer Biomarker No cancer biomarker is absolutely specific No cancer biomarker test is free of false negatives No cancer biomarker test is free of false positives No cancer biomarker is absolutely specific No cancer biomarker test is free of false negatives No cancer biomarker test is free of false positives Antibody Based Cancer Biomarkers Cancer Marker Antibody Cancer CA125 OC 125 ovarian cancer CA 15-3 DF3, 115D8 breast cancer, ovarian cancer CA 549 BC4E549, BC4N154 breast cancer, ovarian cancer CA 27-29 B27.29 breast cancer MCA b-12 breast cancer, ovarian cancer DU-PAN-2 Du-PAN-2 pancreatic cancer, ovarian cancer, gastrointestinal cancers, lung cancer CA 19-9 19-9 pancreatic cancer, liver cancer, gastrointestinal cancers CA 19-5 19-5 pancreatic cancer, ovarian cancer, gastrointestinal cancers CA 50 C50 pancreatic cancer, rectal cancer, gastrointestinal cancers CA 72-4 B27.3, cc49 gastric carcinoma, pancreatic cancer, ovarian cancer CA 242 C242 gastrointestinal cancers pancreatic cancer Her-2/neu Herceptin breast cancer HAb18G/CD147 HAb18 hepatocellular carcinoma, ect Antibody Based Cancer Biomarkers Human genome is 2.91-billion base pairs in length (1990) There are about 25,000 genes exist in the human genome (42% have an unknown function) Approximately 12,000 genes that appear to have the capacity to make secreted proteins, all the genes have been determined the entire nucleotide sequences (3141 genes locus on the first chromosome) At May 2006, the first chromosome sequences were completed, at least 1,000 new genes were found. This is the end of 16 year’s Human Ge