婴儿白血病临床.pdf

2012 27 West China Medical Journal Vol.27 No.10 Oct. 2012 1487 IAL1999 12 2011 6 15 ALL6 AML8 1 M4 4 M5 3 1 1 11 2 2 IAL IAL A Clinical Characteristics of Infantile Acute LeukemiaZHANG De-shuang, BAI Xiao-hong, YAO Yu-jia, CHEN Juan. Department of Neonatology, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan, P. R. China Corresponding author: CHEN Juan, E-mail: chenjuan2000@163.com Abstract Objective To observe the clinical and laboratory features of infantile acute leukemia. Methods We respectively reviewed and analyzed the clinical and laboratory data of 15 patients from December 1999 to June 2011. Results In the 15 patients, 6 were acute lymphoblastic leukemia, 8 were acute myeloid leukemia, and the classifi cation of leukemia of the rest one was unknown; among whom, the M4 (4 cases) and M5 (3 cases) subtypes were the most common types, comprising 50% and 37.5% of AML respectively. The clinical manifestations of IAL were various with obviously extramedullary infi ltrations. Of all the patients, one case was not consistent with its immunophenotype in cell morphology and one infant had chromosomal abnormality. Two cases died of infections and intracranial hemorrhage before chemotherapy. Eleven patients gave up the chemotherapy and only two achieved complete remission after induction chemotherapy. Conclusion Infantile acute leukemia (IAL) has poor prognosis, therefore, improving the relevant laboratory tests and effective treatment of IAL is important. Key words Infants; Acute leukemia; Diagnosis; Therapy