肾脏缺血再灌注损伤.doc

Stimulation of FcγRI on Primary Sensory Neurons Increases Insulin-Like Growth Factor-I Production, Thereby Reducing Reperfusion-Induced Renal Injury in Mice HYPERLINK /search?author1=Naoaki+Haradasortspec=datesubmit=Submit Naoaki Harada HYPERLINK /content/185/2/1303.long \l aff-1#aff-1 *, HYPERLINK /search?author1=Juan+Zhaosortspec=datesubmit=Submit Juan Zhao HYPERLINK /content/185/2/1303.long \l aff-1#aff-1 *, HYPERLINK /search?author1=Hiroki+Kuriharasortspec=datesubmit=Submit Hiroki Kurihara HYPERLINK /content/185/2/1303.long \l aff-2#aff-2 ?, HYPERLINK /search?author1=Naomi+Nakagatasortspec=datesubmit=Submit Naomi Nakagata HYPERLINK /content/185/2/1303.long \l aff-3#aff-3 ? and HYPERLINK /search?author1=Kenji+Okajimasortspec=datesubmit=Submit Kenji Okajima HYPERLINK /content/185/2/1303.long \l aff-1#aff-1 * HYPERLINK /content/185/2/1303.long + Author Affiliations *Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Nagoya; ?Department of Physiological Chemistry and Metabolism, University of Tokyo Graduate School of Medicine, Tokyo; and ?Division of Reproductive Engineering, Center for Animal Resources and Development, Kumamoto University, Kumamoto, Japan Address correspondence and reprint requests to Prof. Kenji Okajima, Department of Translational Medical Science Research, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. E-mail address: HYPERLINK mailto:whynot@med.nagoya-cu.ac.jp whynot@med.nagoya-cu.ac.jp ? HYPERLINK /content/185/2/1303.long \l intro-header#intro-header \o Introduction Next Section Abstract Biological role(s) of FcγRI on mouse primary sensory neurons are not fully understood. Sensory neuron stimulation increases insulin-like growth factor-I (IGF-I) production, thereby reducing ischemia/reperfusion (I/R)-induced tissue injury in mice. In this study, we examined whether the Fc fragment of IgG (IgGFc