动脉压力感受性反射ABR功能与脑卒中文件材料.ppt

ABR功能与脑卒中;脑卒中的严重性;Stroke-Prone spontaneously hypertensive rats (SHR-SP）; BRS is an important determinant for stroke ;Sinoaortic denervation (SAD);SAD on the hemodynamic and cerebral ischemia;;SP-SAP on the hemodynamic and cerebral ischemia;hemodynamic and cerebral ischemia in rats with lower BRS;Effects of CR on BP BRS;Effects of CR on serum lipids ; Effects of CR on apoptosis of neural and myocardial cells;Sir2-like proteins (sirtuins) are a family of NAD+-depandent deacetylases. ;Effects of CR on sirtuin;ABR function and Situin;protein;ABR dysfunction prevented the activation of sirtuin by CR;heart;Kidney; proportion surviving;三、ABR功能影响脑卒中的机制;工作假设：;Sham;SAD导致心脏迷走神经张力降低;SAD导致心脏迷走神经张力降低;反射功能缺陷与a7炎性通路;CR和SAD对炎性因子表达的影响;四、脑卒中防治的新策略;Effects of ket on SBP (a single dose, ig);Effects of ket on BRS (a single dose, ig);Effects of long-term treatment with Ket on BP BRS; Time (days) ;;;