二氢杨梅素药理作用研究进展.pdf
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中草药 Chinese Traditional and Herbal Drugs 第 46 卷 第 4 期 2015 年 2 月 ·603 ·
二氢杨梅素药理作用研究进展
侯小龙,王文清,施春阳,童 庆,方建国*
华中科技大学同济医学院附属同济医院 药学部,湖北 武汉 430030
摘 要:二氢杨梅素为藤茶中主要的黄酮类化合物,近年来其药理作用受到广泛关注。本文就 10 余年来二氢杨梅素抗肿瘤、
抗炎、抗氧化、解酒护肝、抗病原微生物、降血糖、抗疲劳和调血脂等方面的研究进展进行综述,为二氢杨梅素的深入研究
及其植物资源的进一步综合开发利用提供科学依据。
关键词:二氢杨梅素;黄酮类;抗肿瘤;抗氧化;抗炎
中图分类号:R285 文献标志码:A 文章编号:0253 - 2670(2015)04 - 0603 - 07
DOI: 10.7501/j.issn.0253-2670.2015.04.027
Research progress in pharmacological effects of dihydromyricelin
HOU Xiao-long, WANG Wen-qing, SHI Chun-yang, TONG Qing, FANG Jian-guo
Department of Pharmacy, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and
Technology, Wuhan 430030, China
Abstract: As a major flavonoid in the leaves of Ampelopsis grossedentata , dihydromyricelin has attracted the wide attention in recent
years. Studies showed that dihydromyricelin has multiple pharmacological effects, such as antitumor, anti-inflammation, anti-oxidation,
blood lipid regulation, anti-temulence and liver protection, antidiabetics, and anti-pathogeny microorganism. We made a summary for
domestic and foreign study literatures for various pharmacological effects of dihydromyricelin in the recent decade, in the expectation of
providing the scientific basis for the in-depth studies, as well as the utilization of dihydromyricelin and its medicinal resource.
Key words: dihydromyricelin; flavonoids; antitumor; anti-oxidation; anti-inflammation
二氢杨梅素 (dihydromyricelin,DMY 或 DHM ) 一步开发、利用和研究二氢杨梅素提供参考。
又称蛇葡萄素( ampelopsin ,AMP )、白蔹素 1 理化性质
(ampelopsin )、双氢杨梅树皮素、双氢杨梅素、福 二氢杨梅素化学名称为 (2R,3R)-3,5,7-三羟基-
建茶素等,是一种二氢黄酮醇类黄酮化合物,1940 2-(3,4,5-三羟基苯基)苯并二氢吡喃-4-酮,分子式为
年,首先从蛇葡萄属植物楝叶玉葡萄 Ampelopsis C H O ,相对分子质量为 320.25 ;为白色针状结
15 12 8
meliaefolia (Hand. –
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