果胶多柔比星纳米混悬剂的制备及初步药效评价_范菲.pdf

1476 Acta Pharmaceutica Sinica 2016, 51 (9): 1476−1482 1, 2 1, 2* 1 2 2 1, 2 范 菲 , 唐小海 , 黎 霞 , 冉茂盛 , 李玲芳 , 彭 琳 (1. , 610101; 2. , 401336) : (pectin-doxorubicin conjugate, PDC) , (polydispersity index, PI) , PDC PDC pH 5.1 7.4 (phosphate buffer saline, PBS) (doxorubicin, −1 −1 DOX) 10 mg·kg PDC 10 mg·kg DOX, DOX SKOV3 , DOX 1052.5 mg·kg−1 PDC , : PDC 118.8± 6.93 nm, PI 0.14 ± 0.03, zeta −27.2 ± 0.36 mVPDC pH 7.4 PBS , pH 5.1 , 30 h 40% , PDC DOX DOX , , 60 ng·mL−1 , PDC SKOV3 , , PDC : ; ; ; ; : R943 : A : 0513-4870 (2016) 09-1476-07 Preparation and evaluation of pharmacodynamic of the pectin-doxorubicin conjugate nanosuspensions 1, 2 1, 2* 1 2 2 1, 2 FAN Fei , TANG Xiao-hai , LI Xia , RAN Mao-sheng , LI Ling-fang , PENG Lin (1. College of Life Science, Sichuan Normal University, Chengdu 610101, China; 2. Chongqing Lummy Pharmaceutical Co., Ltd, Chongqing 401336, China) Abstract : This study was conducted to produce pectin-doxorubicin conjugate (PDC) nanosuspensions by high-pressure homogenization, and investigating the physico-chemical properties, the cumulative release rate in vitro and in