胰岛素样生长因子-1在新生儿高胆红素血症中的变化及意义.pdf
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11 5 中国当代儿科杂志 Vo.l11 No.5
2009 5 ChinJContempPediatr May2009
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刘芳, 余唯琪, 宋霞, 袁二伟, 李怀营
(兰州大学第一医院, 甘肃 兰州 730000
[ ] -1(IGF-1 ,
。 ( IGF-1(NBNA
IGF-1。 57 25
IGF-1 , (TSB、 (USB (ALB, USB ALB
(B/A, NBNA。 TSB 221 ~ 256 μmol/L, 257 ~ 34 2 μmol/L, 342 μmol/L
、、; TSB 85 μmol/L。 、、 IGF-1 39.38 ±8.4 2,
30.77 ±4.65, 26.34 ±2.05 ng/L, 50.16 ±15.73 ng/ L, 、、 IGF-1
(P 0.01 , ;、、 NBNA 35.0 1±2.26, 32.45 ±
2.74, 26.77 ±5.02, 38.24 ±0.78 (P 0.01 , (P 0.01 ; IGF-1
NBNA (r=0.603, P 0.0 1 , B/A (r=-0.483, P 0.01 。
IGF-1, ;IGF-1。
[ , 2009, 11 (5 :357-3 60]
[ ] -1;;;
[] R7 22 [] A [] 1008-8830(2009 05-0357-04
Serum levelsofinsulin-likegrowthfactor-1 inneonateswithhyperbilirubinemia
LIUFang, YUWei-Q, iSONGXia, YUANEr-We,iLIHua-iYing. FirstHospitalofLanzhouUniversity, Lanzhou730000,
China(LiuF, Emai:llucy yx1996@ 163.com
Abstrac:tObjective Insulin-likegrouthfactor-1 (IGF-1 ispolypetidehormonethathasdemonstratedeffectson
neuralcells.Uptonow, thereisfew reportsabouttherelationbetweenserum IGF-1 andbraindamageinneonateswith
hyperbilirubinemia.Thisstudyexploredthepotentialroleofserum IGF-1 inneonatalhyperbilirubinemia.M ethods Serum
levelsofIGF-1 weremeasuredusingECLIA in57 term neonateswithhyperbilirubinemiaand25 normalterm neonates.
Meanwhil,e totalserum bilirubin(TSB, unconjugatedbilirubin(USB andserum albumin(ALB contentswere
measuredbytheautomaticbiochemistryanalyzerandtheratioofUSB/ALB(B/A wascalculated.Thehyperbilirubinemia
groupwasclass
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