过继性免疫细胞治疗临床应用中的几个问题-中国细胞生物学学报.pdf

网络出版时间：2014-08-28 16:08 网络出版地址：/kcms/doi/10.11844/cjcb.2014.10.0049.html 中国细胞生物学学报 Chinese Journal of Cell Biology 2014, 36(9): DOI: 10.11844/cj cb.2014.10.0049 过继性免疫细胞治疗临床应用中的几个问题 黄 浩 张正涵 Allen Edward Goldenthal 罗成林 罗晓玲* (深圳市合一康生物科技有限公司临床医学中心, 深圳515000) 摘要 过继性细胞免疫治疗(adoptive cell therapy, ACT)是肿瘤免疫治疗的重要组成部分, 在 我国发展非常迅速, 然而其临床应用一直存在很大争议, 甚至在有关临床疗效的争议中一度沉寂。 而近几年, 随着免疫技术的提高, ACT技术再次引起临床工作者的重视, 作者就ACT技术发展历程 和临床应用过程中细胞类型选择、细胞数量确定、疗效评价等问题作一个简单的综述。 关键词 肿瘤; 免疫治疗; 过继性细胞免疫治疗 Several Questions Related to Adoptive Cellular Immunotherapy in Clinical Practice Huang Hao, Zhang Zhenhan, Allen Edward Goldenthal, Luo Chenglin, Luo Xiaoling* (Clinical Center of Shenzhen Hornetcorn Biotechnology Co. Ltd., Shenzhen 515000, China) Abstract During the past decade, adoptive cell therapy (ACT) was quickly developed in our country as one of the most important compositions of tumor immunotherapy. However, its clinical efficacy remains controversial. ACT technology caused the attention of clinical physicians once again with the improvement of immune technique in recent years. We have made a simple review in this article from the following aspects, which including the process of ACT technology development and selection of cell type during the clinical application, determination of cell number, evaluation of curative effect and other issues. Key words cancer; immune therapy; adoptive cell therapy 肿瘤已经成为威胁国人生命的第一大要素, 而 效评价的问题作一简单的综述。 随着环境污染的进一步加重, 肿瘤的发病率、死亡 率均呈不断上升趋势, 与之相应的是常规手术、放 1 ACT技术的发展历程