异麦芽低聚糖对肠道菌群的调节作用_顾清.pdf

32 1 Vol . 32 No. 1 54 2003 1 JOURNAL OF HYGIENE RESEARCH Jan . 2003 :( 2003) 顾清 杨溢 江国虹 常改 300011 : 本研究观察了异麦芽低聚糖对肠道菌群的调节作用 物实验: BABLC 小鼠40 只 随机分为3 个剂量组( 低中高) 和1 个对照组 每组10 只每组 物经口给与相应剂量的异麦芽低聚糖 对照组给水 7 天后留取各组小鼠粪便分析肠道菌群人体实验: 30 名健康成人( 女15 人 男15 人) 每天服用30g 含异麦 芽低聚糖的产品( 相当于15g 异麦芽低聚糖) 7 天后留取粪便进行肠道菌群分析 结果表明: 异麦芽低聚糖对 BALBc 小鼠和受试人群的肠道菌群均具有 一定的调节作用; 对小鼠和人肠道的双歧杆菌人肠道中的乳杆 菌具有增殖作用 并具有抑制人肠道产气荚膜梭菌生长的作用 : 异麦芽低聚糖 肠道菌群 肠功能调节作用 : R7301 R7357 Q566 :A Study on the regulative effect of isomaltooligosaccharides on human intestinal flora Gu Qing Yang Yi Jiang Guohong Chang Gai Tianjin Centers for Disease Control and Provention Tianjin 300011 China Abstract : Objective In order to study the eff ect of Isomaltooligosaccharides on Hum an and mouse intestinal flora in vi vo. M ethods 1. 30 health subject s ( 15 male 15 f emale) were randomly selected from the clinic of Tianjin CDC . They w ere provide 15 g Isom altooligosaccharides once a day for 7 days; 2. 4 0 BABLc mice w ere divided into 4 groups 3 ex perimental groups and 1 control group . These 3 experimental groups w ere f ed different dose of Isomaltooligosaccharides by gavage f or 7 days. Feces of both human and mice were determ ined before and at the end of the experiment . Result s The re sult s show ed that the reproduction of Bif idob acteria and Lactobacillus greatly increased and the growth of Clostridium per friengenes w as significantly inhibited b