神经阻滞与超短波低频脉冲电综合治疗.doc

草乌甲素联合玻璃酸钠治疗老年膝关节炎的疗效观察 潘国兴1 张昕2 杜冬萍2△ （1上海市浦东新区老年医院疼痛科，上海201314；2上海市交通大学附属第六人民医院疼痛科，上海200233） 摘要 目的：观察草乌甲素联合玻璃酸钠与玻璃酸钠注射治疗老年膝关节炎的临床疗效的差异。方法：老年膝关节炎患者例随机分和对照组对照组［1］结论：PAN Guo-Xing, ZHANG Xin, DU Dong-ping (Department of Pain Management,Shanghai Pudongxinqu geriatric Hospital,Shanghai 201314) Abstract Objective: To observe the clinical effects betweeen Bulleyaconitine A combination sodium hyaluronate and sodium hyaluronate injection alone in the treatment of senile knee osteoarthritis. Methods: 90 cases of elderly patients with knee arthritis, were randomly assigned to observer group and the control group, each group of 45 cases. Observation group received sodium hyaluronate intra-articular injection and taking Bulleyaconitine A tablets; control group only received intra-articular injection of sodium hyaluronate. Using Visual analogue pain scores (Visual analogue scale, VAS) as the pain level assessment index, Lenquesne knee scores to assess treatment effect [1]. Observing the therapeutic effect on before treatment and after treatment 1, 2, 4, 8 weeks in two groups patients. Results：Compared with prior treatment, two sets of scores were significantly reduced on posttreatment (P0.05), as far as two sets of scores are concerned , observer group declined more significantly, differences significant (P0.05). Conclusion: Bulleyaconitine A combination sodium hyaluronate injection can treat senile knee osteoarthritis better, with longer curative effect , fewer side effects, and less recurrence rate . Its worth to be used in clinical. Key words: Bulleyaconitine A , sodium hyaluronate, intra-articular injection 骨关节炎（osteoarthritis，OA）是一种以关节软骨的变性、破坏及骨质增生为特征的疾病。其发病率在老年人中日益增高，其中膝关节的骨关节炎(knee osteoarthritis，KOA)能导致关节疼痛和功能障碍严重影响了患者的生活质量［2］。目前临床上对轻中度患者多以服用非甾体类消炎镇痛药及肾上腺皮质激素类药物为主，但副作用较多且只能缓解疼痛症状，停药后多复发。重度患者多采取手术治疗，手术疗效肯定，但手术适应证范围较窄，创伤大，费用高，并发症多，患者心理及经济承受力较差，术后功能锻炼不便等因素决定了大多数患者仍需保守治疗。随着人口老龄化程度的加深，这一问题将会更加突出。因而，采取更安全、更有效的方案来治疗骨性关节炎非常重要。近几年我科开展