妇产科-子宫内膜癌英文PPT课件【45页】.pptx

EndometrialCancerOB/GYNHospitalFudanUniversityXinLU,MD,Ph.D.1.

Endometriodcancer---ContentsIncidenceRiskfactorsClassificationSymptomsPathologyFIGOStagingDiagnosisTreatment2.

WHOCancerReportGlobalcancerratescouldincreaseby50%to15millionby2020Endometrialcanceristhe4thmostcommoncancerinwomenNewDiagnosedcases:142,000Diedcaseseachyear:42,000incidence~2-3%Averageage:60s3.

HistologicTypesEndometrialCancersEndometrioid(87%)Adenosquamous(4%)PapillarySerous(3%)ClearCell(2%)Mucinous(1%)Other(3%)4.

EndometrialCancer:TypeI/IITypeIEstrogenRelatedYoungerandheavierpatientsLowgradeBackgroundofHyperplasiaPerimenopausalExogenousestrogenFamilial/genetic(~15%)LynchIIsyndrome/HNPCCFamilialtrendTypeII(~10%)AggressiveHighgradeUnfavorableHistologyUnrelatedtoestrogenstimulationOccursinolderthinnerwomen5.

EndometrialCancer:RiskFactorsRiskFactorsRelativeRisk[X]Obesity2-5PCOS＞5Estrogenuse10-20Nulliparous3Infertility2-3Diabetes/Hypertension1.3-3Nulliparous3EarlyMenarche(12y/o)1.5-2AtypicalHyperplasiaOC0.3-0.5From:WilliamsGynecology20096.

EndometriumCarcinoma

2009Classification

StageCharacteristicStageI*TumorconfinedtothecorpusuteriIA*NoorlessthanhalfmyometrialinvasionIB*InvasionequaltoormorethanhalfofthemyometriumStageII*Tumorinvadescervicalstroma,butdoesnotextendbeyondtheuterus**StageIII*Localand/orregionalspreadofthetumorIIIA*Tumorinvadestheserosaofthecorpusuteriand/oradnexae#IIIB*Vaginaland/orparametrialinvolvement#IIIC*Metastasestopelvicand/orpara-aorticlymphnodes#.IIIC1*?PositivepelvicnodesIIIC2*?Positiveparaaorticlymphnodeswithorwith