assessing the impact of misclassification error on an epidemiological association between two helminthic infections评估错误分类误差的影响两个蠕虫感染之间的流行病学联系.pdf

Assessing the Impact of Misclassification Error on an Epidemiological Association between Two Helminthic Infections 1,2 ´ ` 1 3 4 Mushfiqur R. Tarafder *, Helene Carabin , Stephen T. McGarvey , Lawrence Joseph , Ernesto 5, Remigio Olveda5 Balolong Jr. 1 Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States of America, 2 Department of Family, Community and Rural Health, The Commonwealth Medical College, Scranton, Pennsylvania, United States of America, 3 International ´ Health Institute, Brown University, Providence, Rhode Island, United States of America, 4 Division of Clinical Epidemiology, McGill University Health Centre, Montreal, Canada, 5 Research Institute for Tropical Medicine, Alabang, Muntinlupa City, Philippines Abstract Background: Polyparasitism can lead to severe disability in endemic populations. Yet, the association between soil- transmitted helminth (STH) and the cumulative incidence of Schistosoma japonicum infection has not been described. The aim of this work was to quantify the effect of misclassification error, which occurs when less than 100% accurate tests are used, in STH and S. japonicum infection status on the estimation of this association. Methodology/Principal Findings: Longitudinal data from 2276 participants in 50 villages in Samar province, Philippines treated at baseline for S. japonicum infection and followed for one year, served as the basis for this analysis. Participants provid