谷氨酰胺对慢性冷应激雏鸡肝脏损伤的影响（可编辑）.doc

谷氨酰胺对慢性冷应激雏鸡肝脏损伤的影响 I Abstract Effects of Glutamine to the Liver Injured by Chronic Cold Stress in Chicken Abstract The cold stress is a universal stress factor to animals, especially newborn animals in cold region. it often evokes the growth performance and the resistance to descend, it has become the main reason that restricts the advance of the stock farming,therefore,the development of medicine or nutrient that can anti-cold stress has become one of the hot topics for the nutrition physiologyso far, there are researches show that the glutamine glutamine,Gln can relieve the effects to the stress response, such as trauma,infection,early weaning. 15 days chicken were chose as the experimental materials, Copy chicken model of chronic cold stress, at the same times, Add ? low,middle,and high doses of glutamine in the diet. Detect the subject chickens liver histopathological changes, and the rate of hepatocyte apoptosis, the antioxidant function and NO metabolism in the serum and the liver, the liver function, and the expression of the HSP70mRNA in the liver. The results showed as follows: 1. The activity of the alanine aminotransferase ALT , the aspartate aminotransferase AST, the alkaline phosphatase ALP and the content of the total bilirubin TBIL, the direct bilirubin DBIL, the indirect bilirubin IBIL in the serum of the cold stress group are higher than the control group; the above-mentioned target in the groups added with glutamine are lower than the group of cold stress, high-dose Gln groups are most obvious. total protein TP, albumin / globulin A / Gin the serum of cold stress groups compared with the control group were significantly lower, the two targets of the groups added with glutamine increased compared with the cold stress group, and the mid dle and high-dose group are most obvious. Showed that the high dose of Gln has role with ease on the cold stress injury of chicken liver function2. The activity of the glutathione peroxidase GSH-