孕妇外周血中胎儿有核红细胞用于产前诊断的研究进展.pdf

2006 14 6 7 , (扬 州大学医学院形态实验室, 江苏 225001) : 本文概述孕妇外周血中胎儿有核红细胞的 离与检测用于产前诊断的研究状况, 描述母体外周血中的胎儿细 胞的特点, 胎儿有核红细胞的富集和 离方法, 并对各方法的优点缺点病理性妊娠的意义临床应用存在的问题及 研究进展作 一综述 : 孕妇外周血; 胎儿有核红细胞; 产前诊断 : R714 : A : 1006- 9534 ( 2006) 06- 0007- 03 Research advances in the p renatal d iagnosis by separat ing fe tal nuc leated red blood ce ll from m aternal periph era l b lood LI Q in, WAN G J ian- j un. (M orpholog ic Laboratory of M edical Colleg e of angzhou University, 225001) A bstrac t: The article summ arizes the ins ection status of se arating fetal nucleated red b lood cell from m aternal eri heral blood in renatal diagnosis. Describes the fetal cell characteristics in m aternal eri heral blood, methods of enrichm ent and isolation. And review s the advantage and disadvantage of ins ection m ethod. The sense of athological regnancy. The usefu lness of clin ical a li ance. The existing rob lem s and research advances. K ey w ord s: M aternal Peri heral B lood; Fetal nucleated red blood cells; Prenatal d iagnosis DNA, 2) , , 90, , 3) ( nucleated red blood cel,l NRBC) , , , 4) , 5) ( fetal nucleated red blood cell, FNRBC) , , 2. ( 1) CD36( throm bos ondin), [ 3] 1. , : ( 2) CD71(T fR ), , [ 1] ( 1) : 1893 Schm orl