内质网应激反应与细胞自噬相互作用机制研究进展.pdf

Food and Drug 2016 8 6 443 1. 150076 2. 150076 3. 150076 Q26 A 1672-979X2016 06-0443-05 Research Progress on Interaction Mechanism of Endoplasmic Reticulum Stress Response and Cell Autophagy JI Yu-bin1,2,3, ZHANG Lu1,2, XIN Guo-song1,2,3, LI Ying-lin1,2, YANG Qi1,2, LI Xin1,2, XUE Qin-bing1,2 (1. Research Center on Life Science and Environmental Science, Harbin University of Commerce, Harbin 150076, China; 2. Engineering Research Center of Natural Anticancer Drugs, Ministry of Education , Harbin 150076, China; 3. Postdoctoral Research Center of Drugs Research Institute, Harbin University of Commerce, Harbin 150076, China) Abstract: Endoplasmic reticulum stress reaction can not only lead to apoptosis, but also induce autophagy. Autophagy is a self-digestion process that can maintain intracellular homeostasis and cell survival. The research progress of the interaction mechanism between endoplasmic reticulum stress and autophagy is discussed in this paper, to supply theoretical basis and reference for prevention of cancer and discovery of new target for anticancer drugs by retrieval of relevant literature at home and abroad. Key Words: endoplasmic reticulum stress; autophagy; anticancer; research progress endoplasmic reticulum ER ERS [1]