诊断病理学疾病的病理学诊断.ppt

疾病的病理学诊断Pathological Diagnosisof Diseases DIAGNOSTIC PATHOLOGY Biopsy Cytology Autopsy (Necropsy, Postmortem) The Aims of Diagnostic Pathology Identification of the diagnosis of diseases The basis for clinical treatment Information for evaluating the prognosis 1. Biopsy The origin of routine biopsy materials Therapeutic resection Resected tissue for diagnostic purpose Endoscopic biopsies Shave biopsies Core biopsies Naturally discharged tissues Clear cell carcinoma, the tumor with hemorrhage is well circumscribed and yellowish. Diagnostic resected lymph node, showing metastatic squamous carcinoma A 38-year old male patient with a space-occupying lesion in the first lumber vertebrae, a metastatic carcinoma was suspected, and the final diagnosis is anaplastic large cell lymphoma. (HE) Anaplastic large cell lymphoma showing EMA positivity should not confuse with metastatic carcinoma。 Anaplastic large cell lymphoma showing CD30 positivity. (LSAB method) Anaplastic large cell lymphoma showing CD45RO positivity and confirming the diagnosis. (LSAB method) The Types of Pathological diagnosis of Biopsies A definite pathological diagnosis of a certain disease. A definite pathological diagnosis can not be given, but a certain disease is suspicious. The diagnosis can not be made and only objective descriptions are given. The materials are not sufficient to make the diagnosis. Importance of Clinico-pathological Cooperation Pathological examination is a cooperative effort of clinician and pathologist in disease diagnosis. Pathological diagnosis is a special consultation of clinician to pathologist. Clinician and pathologist should contribute their own duty to make the right diagnosis. Importance of Clinico-pathological Cooperation Application form General information: For example: small B cell lymphoma seldom occur in patient less than 20 years) Information of clinical and ancillary examinations: Tissue plane of a tumor is important for differenti