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十溴联苯醚(BDE-209)对离体条件下小鼠肾脏和脑组织SOD活力和MDA含量的影响.pdf

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2012年第7卷 生 态 毒 理 学 报 ViL7.2012 第2期,209-214 AsianJournalof No上.209-214 Ecotoxicology 织SOD活力和MDA含量的影响 祝星,陈晓晓,杨旭+ 华中师范大学生命科学学院环境科学实验室,武汉430079 摘要:十溴联苯醚(dccabromodiphenyl 8P.g·mL一,采用NEff和TBA法分别测定SOD(superoxide 209染毒浓度的升高,小鼠肾脏和脑组织的SOD活性先升高后降低,较高染毒浓度组的SOD活性与对照组相比显著性降低; 肾脏和脑组织能够产生急性氧化应激.并导致脂质过氧化损伤。 关键词:十溴联苯醚;超氧化物歧化酶;丙二醛;氧化损伤;小鼠;肾脏;脑 文章编号:1673—5897(2012)2-209-06中图分类号:X171.5文献标识码:A Effectsof SODActivitiesand Ether(BDE-209)on Decabromodiphenyl MDA inMouse andBrain invitro Contents Kidney Tissues:AnStudy Zlm Xu’ Xing,ChenXiaoxiao,Yang Envkonmental ofLife of Normal Laboratory Sciemce,CoIlegeScience,HuazhongU11iVClSity,wulum430079,China Received17Dec豇nber2011 5 2012 accepted January a used Abstract:Asmost brominatedflatne envkonmentalriskof ether widely retardant,potential deeabromodiphenyl attractedmoreandmoreattention.Inthis acute effectofBDE- been oxidative (BDE-209)has experhnent,the damage 209onmouse andbraintissuesWills andbraincellsWere todifferentdoses kidney performed.Mousekidney exposed BDE一209/n of ofmalondi- v豇阳,andenzymatic (0,1,2,4,8斗g·mL。1)of activitysuperoxidedismutase(SOD)content determined.OurresultsshowedthatSOD inmouse andbraintissuewereactiva- aldehyde(MDA)Were activity kidney tedatlowdosesand
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