common variants on chromosome 9p21 are associated with normal tension glaucoma常见变异染色体上9 p21青光眼与正常的张力.pdf

Common Variants on Chromosome 9p21 Are Associated with Normal Tension Glaucoma 1 1 2 1 1 Mitsuko Takamoto *, Toshikatsu Kaburaki , Akihiko Mabuchi , Makoto Araie , Shiro Amano , 1 1 3,4 5 5 Makoto Aihara , Atsuo Tomidokoro , Aiko Iwase , Fumihiko Mabuchi , Kenji Kashiwagi , 6 7 8 8,9 10 Shiroaki Shirato , Noriko Yasuda , Hidetoshi Kawashima , Fumiko Nakajima , Jiro Numaga , Yoshiya Kawamura11, Tsukasa Sasaki12, Katsushi Tokunaga2 1 Department of Ophthalmology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2 Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3 Department of Ophthalmology, Tajimi Municipal Hospital, Gifu, Japan, 4 Tajimi Iwase Eye Clinic, Gifu, Japan, 5 Department of Ophthalmology, University of Yamanashi, Yamanashi, Japan, 6 Shirato Eye Clinic, Tokyo, Japan, 7 Department of Ophthalmology, Tokyo Metropolitan Police Hospital, Tokyo, Japan, 8 Department of Ophthalmology, Saitama Red Cross Hospital, Saitama, Japan, 9 Department of Ophthalmology, Showa General Hospital, Tokyo, Japan, 10 Department of Ophthalmology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan, 11 Department of Psychiatry, Yokohama Clinic, Kanagawa, Japan, 12 Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan Abstract Although intraocular pressure (IOP) is the most definitive cause of glaucoma, a subtype of open angle