跑台运动干预膝关节软骨全层缺损修复.doc

跑台运动干预膝关节软骨全层缺损修复 赵森泉1，毛新润2 (1河北软件职业技术学院，河北省保定市 071000；2河北医科大学第二附属医院，河北省石家庄市 050000) 引用本文：赵森泉，毛新润. 跑台运动干预膝关节软骨全层缺损修复[J].中国组织工程研究，2017，21():2478-2483. DOI:10.3969/j.issn.2095-4344.2017.16.004 ORCID: 0000-0002-5224-8732(毛新润) 文章快速阅读： 文题释义： 膝关节半月板软骨缺损：膝关节半月是一种月牙状纤维软骨，充填在股骨与胫骨关节间隙内，每个膝关节有两个半月板，内侧半月板与外侧半月板。它们的周围部分较厚，附着于胫骨平台的边缘而中央部分则较薄，其接触股骨髁的上面略凹陷而接触胫骨髁的下面则平坦，膝关节半月板中内分无血液供应区，其营养主要来自滑液，只有与胫骨缘连接的边缘部分能从滑膜得到血液供应。 软骨细胞：幼稚的软骨细胞位于软骨组织的表层，单个分布，体积较小，呈椭圆形，长轴与软骨表面平行，越向深层的软骨细胞体积之间增大呈圆形，细胞核圆形或卵圆形，染色浅，细胞质弱嗜碱性，常见数量不一的脂滴。成熟的软骨细胞多2-8个成群分布于软骨陷窝内，这些软骨细胞由同一个母细胞分裂增殖而成，称为同源细胞群。 摘要 背景：关节软骨位置特殊，其功能常会受到运动的影响，通过关节运动能促进缺损部位修复，但是该结论尚未得到进一步证实。 目的：探讨跑台运动时不同运动强度对大鼠膝关节软骨全层缺损修复效果。 方法：将40只大鼠用直径3.2 mm的骨科手术电钻在股骨面制作一个直径3.2 mm的全层软骨缺损模型，然后随机分为模型组、低强度运动组、中强度运动组和高强度运动组，各10只。模型组仅在笼内自由活动，低强度运动组在平面进行运动，平台速度8.2 m/min；中强度运动组跑台坡度设置成5°，速度控制在 15.5 m/min；高强度运动组设置跑台高度10°，速度控制在26.7 m/min。Effect of treadmill exercise on the repair of full-thickness knee cartilage defects Zhao Sen-quan1, Mao Xin-run2 (1Hebei Software Institute, Baoding 071000, Hebei Province, China; 2the Second Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei Province, China) Abstract BACKGROUND: As the articular cartilage has a special anatomical position, its function is often affected by movement. Whether exercise training can promote the cartilage repair still needs to be confirmed. OBJECTIVE: To investigate the effects of different intensities of treadmill exercises on the repair of full-thickness articular cartilage defects in rats. METHODS: Forty rats were selected, and the models of full-thickness articular cartilage defects (3.2 mm in diameter) on the femoral surface were made with a orthopedic drill, followed by randomized into model, low-, moderate- and high-intensity exercise groups (n=10 per group). The rats in the model group were allowed free cage activity. The rats in the low-intensity exercise group exercised on the platform, and the platform speed was 8.2 m/min; rats in the middle-intensity exercise group ex