【精品课件教案ppt】 经皮二尖瓣修复术（mitraclip）的研究进展.ppt

ACCESS-EU研究入选标准 MitraClip Patients Treated in ACCESS-EU N = 567 N = 22 Data not available N = 45 Withdrawals 1-year follow-up complete 86% patient data available Discharge N = 551 N = 3 Data not available N = 13 Withdrawals 1 Year Follow-up N = 487 基线资料 Demographics and Co-morbidities EVEREST II RCT Device Patients N=178 EVEREST II High Surgical Risk Cohort N=211 ACCESS EU – MitraClip Patients N=567 Age (mean ± SD), years 67 ± 13 76 ± 10 74 ± 10 Logistic EuroSCORE, (%) Mean ± SD NA NA 23 ± 18 Logistic EuroSCORE ≥ 20%, (%) NA NA 45 STS Mortality Risk, (%) Mean ± SD 5 ± 4 12 ± 8 NA STS Mortality Risk ≥ 12%, (%) 6 48 NA Male Gender, (%) 64 61 64 Coronary Artery Disease, (%) 47 81 63 Previous Cardiovascular Surgery, (%) 23 58 37 Myocardial Infarction, (%) 22 49 32 Cerebrovascular Disease, (%) 8 21 13 Moderate to Severe Renal Failure, (%) 3 31 42 Atrial Fibrillation, (%) 33 64 68 NYHA Functional Class III or IV, (%) 50 86 85 基线资料 Demographics and Co-morbidities EVEREST II RCT Device Patients N=178 EVEREST II High Surgical Risk Cohort N=211 ACCESS EU – MitraClip Patients N=567 Mitral Regurgitation Grade ≥ 3+, (%) 96 86 98 Ejection Fraction 40%, (%) 6 28 53 Functional MR, (%) 27 71 77 Ischemic NA NA 42 Non-ischemic NA NA 58 Degenerative MR, (%) 73 29 23 MitraClip Implant Rate and Number of Clips Implanted 99.6% Implant Rate N=567 30天终点事件-EuroSCORE高危Logistic回归 1-Year Events* All PatientsN=567 Logistic EuroSCORE ≥20% N=253 Logistic EuroSCORE 20% N=314 p-value Death 19 (3.4%) 11 (4.3%) 8 (2.5%) ns Stroke 4 (0.7%) 3 (1.2%) 1 (0.3%) ns Myocardial Infarction 4 (0.7%) 2 (0.8%) 2 (0.6%) ns Renal Failure 27 (4.8%) 16 (6.3%) 11 (3.5%) ns Respiratory Failure 4 (0.7%) 3 (1.2%) 1 (0.3%) ns Need for Resuscitation 10 (1.8%) 7 (2.8%) 3 (1.0%) ns Cardiac Tamponade 6 (1.1%) 3 (1.2%) 3 (1.0%) ns Bleeding Complications 22 (3.9%) 12 (4.7%) 10 (3.2%) ns * As reported by the sites Site Reported Safety Events At 1 Year 1-Year Events* All PatientsN=567 Logistic EuroSCORE ≥20% N=2