异氟烷预处理对大鼠心肌缺血再灌注损伤的保护作用.pdf

() 　Fudan Univ J Med Sci 2008 Jul, 35 (4) 539 △ ■ 姜　琳 　王　琛　覃　琴　刘　霞　朱　江　谢　红 (　　215004) 【】　　, 。　, 30 min、30 min( )、 15 min、30 min 2 h。 48 Sprague Dawley 6: C N 、DMS 、PTN 、IS 、PTN+IS IS +PTN 。C N , ;DMS 15 min (DMS );PTN 15 min NF-κB (parthenolide, PTN)500μg/kg;IS 1.0M AC (IS )30 min, 15 min ; PTN+IS IS +PTN 、15 min PTN 500 μg/kg。 , (TPT)。　, (HR), (MAP)-(RPP)(P0.05)。 IS 、PTN+IS IS +PTN HR、MAP RPP (P0.05)。1 h 2 h MAP RPP (P0.05)。 C N (52.48±6.04)%, IS (36.82± 4.99)%, PTN+IS (51.56±3.15)%IS +PTN (51.06±1.05)% IS (36.82±4.99)% (P0.05)。　, 。PTN , NF-κB 。 【】　;　;　;　;　NF-κB + 【】　R 971 .2　　【】　A Protective effect of isoflurane preconditioning on myocardium against ischemia-reperfusion injury in rats JIANG Lin, WANG Chen, QIN Qin, LIU Xia, ZHU Jiang, XIE Hong■ (Departmentof Anesthesiology, Second Aff iliated Hospital, Soochow University , Suzhou 215004, JiangsuProvince, China) 【Abstract】　Objective　To investigate the myocardial infarct size and the protective effect of isoflurane preconditioning on myocardium against ischemia-reperfusioninjury in rats and the possible mechanism. Methods　Myocardial ischemia-reperfusion injury model was instrumented in Sprague Dawley (SD) rats.All rats, except for the control group, were subjected to 30 min of equilibration, 30 min of isoflurane exposure and 15min washout, followed by 30 min of left coronary artery occlusion and2 h of reperfusion.Forty-eight male SD rats were randomly divided into six groups:C N group, DMS group,PTN group,IS group, PTN+IS group and IS +PTN group.C N group:rats experienced myo