厌氧性细菌（英文PPT）.pdf

Anaerobic Bacteria 1 Brief Introduction Classification Classification Spore-forming anaerobe -- Clostridium C.tetani (G+ bacilli) C.botulinum exist in nature Non-spore-forming anaerobe -- polymorphic + - + - (G and G cocci, G and G bacilli ) members of normal flora Infection Spore-forming Non-spore-forming exogenous endogenous exotoxin endotoxin other invasive factor typical clinical symptom similar symptom abscess inflammation septicemia treatment by antitoxin treatment by antibacterial drug Section 1. Clostridium 1. Clostridium tetani Biological Properties ➢ Morphology G+, peritrichous flagella, no capsule, spore –round, terminal spore (“drum-stick”) ➢Culture obligate anaerobe blood agar -- completely hemolysis, feather colony ➢Resistance several years in soil; 100℃ 1hr (spore) sensitive to penicillin (vegetative) Pathogenicity Immunity ➢Pathogenic Condition deep, narrow and mixture with soil Wound + Spore necrotic tissue pyogenic bacteria mixture infection (puncture, gun shoot, burn, animal bite) Pathogenicity Immunity ➢Pathogenic Factor * tetanolys